Аmoxicillin trihydrate

Pharmacological action
Sun (bactericidal). Stable in the acidic environment, eating does not affect the removals. Easily passes gistogematicalkie barriers, unchanged except GEB and penetrates into most tissues and organs; accumulates in therapeutic concentrations in the peritoneal fluid, urine, content skin blisters, pleural effusion, lung, the lining of the intestine, female genital mutilation, fluid middle ear, gall bladder and bile tissues of the fetus. Partly metabolised education inactive metabolites excreted by the kidneys in an unmodified form, the liver. In a small amount is excreted in breast milk. Effect develops through 15-30 minutes after administration and lasts for 8 hours Has a wide spectrum antimicrobial action, including Staphylococcus spp., in addition to the strains producyrute penitsillinazou, Streptococcus spp., Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Proteus mirabilis, some strains of Salmonella, Shigella, Klebsiella, and Haemophilus influenzae.


Indications for using

Infections of the respiratory tract and LOR-organov (bronchitis, pneumonia, tonsillitis, acute otitis media, pharyngitis, sinusit), the genitourinary system (urethritis, cystitis, pyelonephritis, endometritis, uncomplicated gonorrhoea), the skin and soft tissues, blood (peritonitis, enterocolitis, cholecystitis, cholangitis, typhoid fever); leptospirosis, listeriosis, meningitis, Lyme disease (Lyme disease), prevention of endocarditis and surgical infections; combination therapy of gastritis and peptic ulcer disease (in combination with metronidazolom), sepsis (together with aminoglikozidami).


Contraindications
Hypersensitivity (including from other penitsillinam, zefalosporynam, carbapenemam), allergic diathesis, bronchial asthma, hay fever, infectious mononucleosis, lymphoblastic, gastrointestinal diseases in history (especially colitis associated with antibiotic use).


Side effect
Nausea, vomiting, diarrhoea, pain in the anus, stomatitis, glossit; agitation, anxiety, insomnia, sputannosti consciousness, behavior change, headache, dizziness, convulsions reactions; difficulty breathing, tachycardia; joint pain; interstitial nephritis; goiter, superinfection, candidiasis of the mouth or vagina, pseudomembranous or hemorrhagic colitis; moderate increase in transaminaz in blood, transient anaemia, trombozitopenica purpura, eosinophilia, leukopenia, neutropenia and agranulozitos, allergic reactions: exfoliative dermatitis, exudative erythema multiforme, Stevens - Johnson, anaphylactic shock, makulopapuleznaya rashes, itching, urticaria, swelling Kwinke, reaction similar to savorotocna disease.


Interaction
Reduces effect estrogensoderjath oral contraceptive products, decreases the clearance and increases the toxicity of methotrexate. Increases the absorption of digoxin. Excretion is slowing probenecid, sulfinpirazon, acetylsalicylic acid, indometacin, oksifenbutazonom, phenylbutazone and other drugs, shock tubular secretion. Antibacterial activity decreases bacteriostatic chemotherapeutics and antacids increases - aminoglycosides and metronidazole. Allopurinol increases the occurrence of skin rashes.


Overdose
Symptoms: nausea, vomiting, diarrhoea, violations vodno-elektrolitnogo balance. Treatment: washing stomach, the appointment of activated carbon, salt laxatives, correction vodno-elektrolitnogo balance; hemodialysis.


Special instructions
Be wary when using urticaria and hay fever. You should periodically monitor kidney function, liver and haematopoiesis with long-term therapy. Treatment must continue 48-72 hours after the disappearance of clinical signs of disease. When pregnancy and lactation are used for health, taking into account the expected effect for the mother and the potential risk to the fetus or child. During the course breastfeeding excluded.  In determining glucose in the urine may be false-positives and change results on determination of urobilinogen.